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The skeletal losses are due in part to the low estradiol levels during lactation which stimulate osteoclast number and activity
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89 Under extreme hypoxia (1%–2% O₂), the Notch1 and extracellular signal-regulated kinase 1/2 (ERK1/2)/p38 mitogen-activated protein kinase (MAPK) signaling pathways are activated in BMSCs, leading to suppressed osteogenic differentiation
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