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127 This reporter consists of the ERK binding domain of Elk-1, an NLS, and a nuclear export signal (NES), so that upon activation and nuclear localization of ERK, phosphorylation of the reporter leads to activation of the NES, deactivation of the NLS, and resultant cytoplasmic localization of the Clover fluorescent signal
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Lead Researcher Spotlight Professor Frank Ng, PhD Department of Biochemistry and Molecular Biology Monash University, Melbourne, Australia Professor Frank Ng led the pioneering research team that developed AOD-9604 in the 1990s as part of efforts to create a targeted anti-obesity therapeutic derived from human growth hormone
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