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Using mice with keratinocyte-specific deficiency in glutamate cysteine ligase, they showed that glutathione deficiency led to increased cell death through apoptosis, ferroptosis, and necroptosis, with elevated reactive oxygen and nitrogen species causing DNA and mitochondrial damage
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[DOI] [PubMed] [Google Scholar] Sotiropoulos A, Ohanna M, Kedzia C, Menon RK, Kopchick JJ, Kelly PA, et al
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