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The activity of eluted fractions were assessed, and the active and homogenous fractions were gathered, concentrated by 30 kDa centrifugal membrane [30]
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The molecular mechanism of IMQ-induced erythema involves the activation of immune responses through TLR7 signaling, which subsequently triggers the release of pro-inflammatory mediators, including chemokine (C–C motif) ligand 2, IL-1β, IL-6, and TNF-α
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