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Long-term aerobic glycolysis can uncouple enzymes of normal OXPHOS, causing a chronic Warburg effect and accumulation of intracellular fatty acids, nucleotides, amino acids, and, through the activation of the polyol-mechanism, sorbitol and sorbitol-attracted water (Singh et al., 2021
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In some cases, doctors will prescribe a potassium supplement to prevent depletion
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