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Common hormonal MTHFR symptoms include: Severe PMS — mood swings, breast tenderness, bloating, and irritability before periods Irregular or heavy periods — unpredictable cycles or excessive menstrual bleeding Infertility and difficulty conceiving — reduced egg or sperm quality or implantation issues Recurrent miscarriages — often linked to elevated homocysteine and poor methylation Chronic fatigue and low energy — feeling exhausted even after adequate sleep Thyroid dysfunction — sluggish metabolism, weight gain, or cold sensitivity Fibrocystic breasts and ovarian cysts Endometriosis and uterine fibroids Why this happens: Poor methylation leads to oestrogen dominance (too much oestrogen relative to progesterone) because your body can’t efficiently break down and eliminate used hormones

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Plasma and dietary vitamin C levels and risk of gastric cancer in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)