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Thymosin Beta-4 itself has been studied in humans more than TB-500, including trials for dermal wounds, pressure ulcers, and corneal injuries, as well as cardiac repair after ischemia

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This includes bones (ilium, femur, and tibia), tendons (all four parts of the quadriceps muscle ultimately inserted into the tuberosity of the tibia via the patella, where the quadriceps tendon becomes the patellar ligament), joints, neurovascular elements, and the muscles responsible for moving the legs [23]