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Contraindications include use of drugs that alter serotonin or dopamine metabolism (SSRIs, bupropion, lithium, antipsychotics, tricyclic antidepressants, MAOIs, tramadol, triptans) or CYP 2D6-substrate drugs, valvular heart disease, and a glomerular filtration rate (GFR) 60% on drug lose ≥ 5%, and more than one-third lose ≥ 10% 46,48–50
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Size:20 grams (40 days supply)
It’s also why patients must become their own advocate and participate in the process of managing their symptoms
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