glutathione s transferase researcg Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione Research Peptide |

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HF patients who should be screened for GH/IGF-1 abnormalities are those with severe disease, poor functional capacity, high mortality risk, or specific conditions like polytransfused patients , as low IGF-1 levels often signal worse outcomes, making screening useful for prognosis and potentially guiding therapy [97]

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The preservation of proteostasis plays a crucial role in cell survival and becomes even more important for nondividing cells such as neurons, whose proteostasis machineries are reduced with aging, causing an accumulation of damaged organelles and misfolded proteins (327–329)