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Approved oncology drugs exist specifically to inhibit this pathway: capmatinib and tepotinib are approved for MET exon 14 skipping non-small-cell lung cancer, crizotinib is a multi-target inhibitor with MET activity, and savolitinib is approved in China
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It was found that the mentioned microplastic activates the p38 MAPK pathway and reduces the Nrf2 molecule and ultimately causes oxidative stress
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