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Here is a practical sequence to consider: Start with daily broad-spectrum sunscreen, applied every morning regardless of weather Introduce a retinoid gradually, starting two to three nights per week Add a topical GHK-Cu serum as a complementary step, ideally at a different time of day than retinoid use Monitor your skin for irritation and adjust frequency as needed Reassess results every 8 to 12 weeks, since this mirrors the timeline used in most GHK-Cu studies Discuss persistent concerns with a primary care or wellness provider This structured approach reduces the risk of over-exfoliating or combining ingredients incorrectly