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When cells encounter harmful external signals, Nrf2 dissociates from Keap1 in the cytoplasm and translocate into the nucleus, promoting the expression of antioxidant-related proteins, including superoxide dismutase (SOD), glutathione peroxidase, and catalase (CAT), thereby increasing the intracellular levels of glutathione (GSH)
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For example, combining PI3K inhibitors with antibodies against the key immune checkpoint proteins PD-1/PD-L1 has improved antitumor responses in preclinical models by augmenting T-cell-mediated tumor cell killing and reducing immunosuppressive cell populations within the tumor microenvironment
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