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The overactivation of microglia leads to the release of pro-inflammatory factors such as Interleukin-1 beta (IL-1β), Tumor Necrosis Factor-alpha (TNF- α ), and Interleukin-6 (IL-6), which directly damage dopaminergic neurons in the substantia nigra pars compacta (SNpc) (McCarty and Lerner, 2020)
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