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Furthermore, methadone is also an N -methyl-d-aspartate (NMDA) receptor antagonist, and this property has been implicated in a role of preventing tolerance to methadone
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Additionally, the changes of the phosphorylation of cytoskeletal proteins, glial fibrillary acidic proteins, and vimentins by the pathological level of propionate in PA patients could contribute to the neurological dysfunction observed in PA (de Almeida, Funchal, Gottfried, Wajner, & Pessoa-Pureur, 2006
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