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2 Parkinson’s at a glance and their pathophysiology PD is a chronic and progressive neurological disease that generally impacts the cortico-basal ganglia-thalamic circuitry in the brain ( 2.1 Pathophysiology of Parkinson’s disease 2.1.1 Mechanism of neurodegeneration PD is caused by the progressive degradation of dopaminergic nerve cells in the substantia nigra, a part of the brain that is essential for controlling movement ( OS is a prevalent phenomenon in the brain in PD, resulting from an imbalance between the production of deleterious chemicals known as reactive oxygen species (ROS) and the brain’s capacity to neutralize them ( 2.1.2 Role of alpha-synuclein A small soluble protein (alpha-nuclein) is present in the brain in large amounts, mainly at the presynaptic terminals, and is expected to plays an important role in synaptic function and neurotransmitter release ( Moreover, these proteins may misfold, further impair proteasomal and autophagic pathways