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Furthermore, growing evidence suggests that post-vaccination adverse events, especially when persistent, may reflect an unbalanced immune response rather than a simple humoral response, with possible involvement of innate immunity and cytokine signaling mechanisms [169]
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The conversion of dUDP to dTMP is catalyzed by thymidylate synthase, which requires folate (N5,N10 methylene tetrahydrofolate) as a methyl and hydrogen donor to complete this conversion (figure 7.13)
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