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In experiments using CYP2E1 KO ( CYP2E1 −/− ) mice, no difference was observed in alcohol metabolism rates between CYP2E1 −/− and wild-type mice at various EtOH doses [117]
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The SAR studies revealed that compound 1c showed enhanced tyrosinase inhibitory activity due to the presence of a 2,4-dihydroxyphenyl group [61]
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