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doi:10.1007/s00702-012-0893-9 · PubMed 23008029 Frequently Asked Questions In the two placebo-controlled PREEMPT trials (687 patients on Botox, 692 on placebo), the adverse reactions the FDA label lists as more frequent with Botox were neck pain (9% versus 3%), headache (5% versus 3%), migraine (4% versus 3%), eyelid droop or ptosis (4% versus under 1%), musculoskeletal stiffness (4% versus 1%), muscle weakness (4% versus under 1%), and myalgia, musculoskeletal pain, injection-site pain, bronchitis, facial weakness, and muscle spasms each at 2–3%