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On the other hand, the strategy of lipid suppression or induction of lipid peroxidation + ICI is expected to overcome immune tolerance by improving antigen presentation and immunoinflammatory microenvironment ( 4.3 Biomarker development and patient stratification based on metabolic pathways Multi-omics stratification is being formed: integrated analysis of transcriptome–lipidome–immune infiltration reveals that there is a coupling relationship between the strength of lipid metabolic gene pathway and CD8 + T cell infiltration/function, and survival outcome, which can be used to guide the priority of “metabolism-immune” combination ( 5 Continuous challenges and future prospects: prospects of precision metabolic oncology 5.1 Tumor–metabolic pathway plasticity of host and organ specificity The plasticity of tumor metabolism makes it diverse in different microenvironments

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