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The genomic effect of GR in the nucleus can either be direct via the binding of GR on specific positive or negative binding sites in DNA, named GRE (glucocorticoid response element) or negative-GRE (nGRE) or indirectly via the interaction of GR with other proteins or transcription factors, by a mechanism known as tethering [16]
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[DOI] [PubMed] [Google Scholar] 676
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