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The critical role of Gpx4 is underscored by the fact that whereas Gpx1-knockout mice are fully viable, Gpx4-knockout animals demonstrate embryonic lethality, and Gpx4 +/− cell lines are markedly sensitive to inducers of oxidative stress, including γ-irradiation, tert -butyl-hydroperoxide, and hydrogen peroxide, as compared with cell lines derived from wild-type control littermates (147)
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A vitamin B12 deficiency can be treated with injections known as vitamin B12 shots or b12 infusions, especially if the person’s body has trouble absorbing the vitamin
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