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Abstract CT216: Phase I dose escalating study of 2B3-101, glutathione PEGylated liposomal doxorubicin, in patients with solid tumors and brain metastases or recurrent malignant glioma
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Figure 3 The p38 MAPK pathway is known to be activated by various environmental stressors, including oxidative stress, hypoxia, UV or ionizing radiation, and osmotic disturbances (130), Additionally, the pathway is stimulated by inflammatory factors such as TNF-α (131, 132), IL-1β (133, 134) and TGF-β (135, 136)) as well as by pathogens including bacterial lipopolysaccharides (LPS) (137), which activate toll-like receptors (TLR)
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