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In this setting, metformin has been shown to enhance autophagy’s activity in immune cells (such as CD4 + T-cells), normalize mitochondrial function, reduce the accumulation of reactive oxygen species (ROSs), and shift inflammatory cytokine profiles, particularly Th17 pathways [146]
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The published medical literature on this specific practice consists almost entirely of case reports describing severe complications and the surgical reconstruction required to treat them — not studies of a safe, working procedure
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