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The expression of the antiporter SLC7A11 (Figure 3K), which imports cystine in lieu of glutamate, was found to be depleted by10-fold in WG and 3.5, and 2-folds, respectively, in NT and WT compared to respective controls

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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later