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The Burris laboratory's broader medicinal chemistry work, including a 2020 paper by Schoepke, Billon, Haynes, and colleagues in ACS Chemical Biology characterizing SLU-PP-1072 (a selective ERRα/γ inverse agonist from the same platform), demonstrates that this is an active tool-compound chemistry program — not a clinical development program
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However, the role of BAT PNPLA2 in maintaining thermogenesis has been recently challenged with tissue-specific gene knockout (KO) models
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