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58,98,99,100,101 In addition, the conversion of itaconate to itaconyl-CoA by itaconate-CoA transferase can sequester mitochondrial CoA pools (โCoA trapโ), limiting available CoA, decreasing substrate-level phosphorylation efficiency, and constraining ATP and GTP synthesis, thereby further suppressing complex II function
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The GLS2 gene, located in chromosome 12, encodes two splice variants with low activity and allosteric regulation, liver-type glutaminase (LGA, short transcript isoform), and glutaminase B (GAB, long transcript isoform), which are highly expressed in the normal adult liver
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