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Hwang HJ, Lee YR, Kang D, et al
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El péptido del autoantígeno, abrazado por una molécula HLA clase II, es presentado por una célula presentadora de antígeno a un CD4 T helper naive (Th0), el cual se activa y desencadena una cascada de reacciones inmunes determinadas principalmente por las citoquinas: interleuquina 2 (IL-2) e interferón γ, las cuales provocarán el daño celular
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