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14 Neurotransmitter Action: G-Protein-Coupled Receptors G-protein-coupled receptors (GPCRs), also called metabotropic receptors, are membrane-bound proteins that activate G-proteins after binding neurotransmitters
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Copper activates endoplasmic reticulum stress The endoplasmic reticulum (ER) is essential for hepatocytes to maintain lipid metabolism, with its regulatory roles including: (1) ER membrane-localized sterol regulatory element-binding proteins (SREBP-1c, SREBP-2), which regulate DNL-SREBP-1c primarily mediates fatty acid synthesis, while SREBP-2 controls cholesterol synthesis
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