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4-Octyl Itaconate Attenuates Cell Proliferation by Cellular Senescence via Glutathione Metabolism Disorders and Mitochondrial Dysfunction in Melanoma - Yoshikazu Hayashi, Ayaka Saeki, Shohei Yoshimoto, Ena Yano, Atsushi Yasukochi, Soi Kimura, Tomoe ...
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Inhibition of glutathione metabolism by BSO decreased the ESCC tumor burden To investigate whether glutathione metabolism contributed to the progression of ESCC development, we treated mice bearing ESCC 20 weeks after initial carcinogen treatment with buthionine sulfoximine (BSO), a commonly used chemical inhibitor of γ -glutamylcysteine synthetase (γ-GCS) that decreases tissue glutathione concentrations (Figure 3a)
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